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. 2021 Feb 24;8:595077. doi: 10.3389/fmed.2021.595077

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Copyright © 2021 Vagts, Ascoli, Fraidenburg, Baughman, Huang, Edafetanure-Ibeh, Ahmed, Levin, Lu, Perkins, Finn and Sweiss.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scatterplot in (A) demonstrates the strong direct relationship (Spearman's correlation coefficient; rho = 0.8329, p < 0.001) that is observed between absolute lymphocyte counts (kcells/μL) and absolute CD4+ T-cells (cells/μL). Box and whisker plots in (B) highlight the differences in absolute CD4+ T-cells (cells/μL) that are observed between clusters. A significant association was identified by Kruskal-Wallis test between clusters and absolute CD4+ T-cells (p = 0.0008). Post-hoc analysis with Dunn's test demonstrated significantly reduced absolute CD4+ T-cell counts, denoted with an asterisk (*), in Cluster 3 compared to Clusters 1 and 2 (BH-adjusted p = 0.0005 and 0.0929, respectively). No difference (NS) in absolute CD4+ T-cell counts was observed between Clusters 1 and 2.