Table 3.
Summary of the most relevant characteristics that comprise the UIC-Sarcoidosis cohort clusters.
| Summary of cluster characteristics | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|
| Race | African American | African American | Caucasian |
| Sex(t) | Female | Female | Male |
| Disease Acuity | Chronic | Variable | Acute |
| Lung Parenchyma | Normal | Mixed | Mixed |
| (Nodules & Advanced) | (Nodules & Consolidation/GGO) | ||
| Treatment | Naïve | Combination Corticosteroid & | Corticosteroid Monotherapy |
| Immune modulator | |||
| Markers of Inflammation | Normal | Elevated | Normal |
| Absolute Lymphocytes (kcells/uL)(*) | Normal | Reduced | Reduced |
| Absolute CD4+ T-cells (cells/uL)(*) | Normal | Reduced | Reduced |
| 18FDG-PET/CT | Normal | Positive | Positive |
(t) Indicates that a trend toward significance was observed between clusters (Kruskal-Wallis p = 0.0560).
(*)
Reduced peripheral lymphocyte counts and reduced absolute CD4+ T-cell counts within the UIC-Sarcoidosis cohort clusters are defined as median values ≤ 1.5 kcells/uL and ≤ 500 cells/uL, respectively.