Table 3.

Logistic regression analysis of calcification.

Variables	Univariate		Multivariate
	OR (95% CI)	p value	OR (95% CI)	p value
Age	1.060 (1.021–1.100)	0.002	1.073 (1.019–1.130)	0.008
Gender	1.611 (0.554–4.688)	0.382	0.530 (0.076–3.685)	0.521
Hypertension	1.434 (0.647–3.179)	0.374	2.742 (0.881–8.539)	0.082
Diabetes	1.828 (0.715–4.673)	0.208	1.614 (0.505–5.156)	0.419
Smoking	0.574 (0.224–1.471)	0.248	0.870 (0.189–4.014)	0.859
Triglyceride	1.000 (0.996–1.004)	0.984	1.242 (0.778–1.981)	0.364
LDL-C	1.006 (0.994–1.017)	0.345	1.344 (0.675–2.674)	0.400
HDL-C	1.007 (0.963–1.052)	0.762	3.417 (0.366–31.883)	0.281
eGFR	0.983 (0.961–1.005)	0.119	1.008 (0.978–1.040)	0.598
TMAO	2.246 (1.448–3.484)	<0.001	2.270 (1.358–3.794)	0.002
Hs-CRP	0.996 (0.906–1.094)	0.927	1.050 (0.929–1.188)	0.434
EF	0.978 (0.918–1.042)	0.495	0.965 (0.896–1.039)	0.346
Antiplatelet drug	1.164 (0.351–3.856)	0.804	0.931 (0.132–6.583)	0.943
Statin	1.377 (0.422–4.490)	0.596	0.986 (0.113–8.617)	0.990
ACEI/ARB	0.854 (0.301–2.424)	0.767	0.557 (0.089–3.491)	0.532
β-blocker	0.337 (0.046–2.494)	0.287	0.220 (0.017–2.842)	0.246

Odds ratio shown were for plasma TMAO level as a continuous variable.

eGFR, estimated glomerular filtration rate; HDL-C, high-density lipoprotein-cholesterol; hs-CRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein-cholesterol; EF, ejection fraction; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker and TMAO, trimethylamine N-oxide.