. 2021 Feb 24;12:616712. doi: 10.3389/fmicb.2021.616712

TABLE 1.

Odds ratios comparing the likelihood of superior phage efficacy against E. coli O157 at different incubation temperatures, incubation times, MOIs, phages, and strains of E. coli O157.

Factors^§	Percentage (%) of optical turbidity measurement <0.01	Odds ratio	95% CI^#	P-value*
Temperature, time
22°C, 16 h	75^a	2.96	2.58-3.40	<0.001
22°C, 18 h	75^a	2.88	2.51-3.31	<0.001
22°C, 14 h	75^a	2.80	2.44-3.21	<0.001
37°C, 8 h	72^b	2.40	2.10-2.76	<0.001
22°C, 12 h	72^bc	2.32	2.02-2.66	<0.001
22°C, 10 h	71^bcd	2.13	1.86-2.43	<0.001
22°C, 20 h	71^cd	2.04	1.79-2.34	<0.001
37°C, 6 h	70^d	1.87	1.63-2.14	<0.001
37°C, 10 h	67^e	1.55	1.36-1.77	<0.001
22°C, 22 h	61^h	Referent
MOIs
1,000	88^a	23.39	20.62-26.52	<0.001
100	81^b	11.57	10.35-12.94	<0.001
10	79^c	9.20	8.26-10.25	<0.001
1	73^d	5.97	5.39-6.64	<0.001
0.1	61^e	2.65	2.41-2.92	<0.001
0.01	44^f	Referent
Phages
T1 + T4 + rV5	89^a	109.12	88.88-133.98	<0.001
T5 + T1 + T4 + rV5	87^ab	90.57	74.21-110.52	<0.001
T5 + T1 + T4	86^b	83.03	68.21-101.07	<0.001
T5 + T1	86^b	81.64	67.10-99.32	<0.001
T5 + T1 + rV5	83^c	60.30	49.95-72.78	<0.001
T1 + T4	82^c	56.37	46.78-67.94	<0.001
T5	81^c	51.61	42.91-62.07	<0.001
T5 + T4	79^d	41.66	34.78-49.89	<0.001
T5 + T4 + rV5	67^e	17.74	14.99-20.99	<0.001
T4 + rV5	65^ef	15.95	13.49-18.85	<0.001
T5 + rV5	64^ef	15.45	13.08-18.25	<0.001
T4	63^f	14.41	12.21-17.02	<0.001
T1 + rV5	59^g	11.34	9.62-13.37	<0.001
T1	52^h	7.44	6.32-8.74	<0.001
rV5	19ⁱ	Referent
Bacteria
E. coli O157:H7 CO281-31N (H, PT8)	88^a	27.95	24.15-32.34	<0.001
E. coli O157:H7 H4420N (B, PT87)	80^b	11.42	10.06-12.96	<0.001
E. coli O157:H7 EDL933 (H, PT21)	78^c	9.88	8.73-11.19	<0.001
E. coli O157:H7 E318N (H, PT4)	74^d	7.06	6.26-7.96	<0.001
E. coli O157:H7 R508N (B, PT14)	73^d	6.45	5.72-7.26	<0.001
E. coli O157:NM E32511 (H, PT31)	71^e	5.60	4.98-6.30	<0.001
All 7 mixture	61^f	2.97	2.66-3.32	<0.001
E. coli O157:H7 3081 (B, PT43)	43^g	Referent

^§H, Human; B, Bovine; PT, phage type. ^#CI, confidence interval for the odds ratio. *P-value for the likelihood of superior phage efficacy as affected by different incubation temperatures, incubation times, MOIs, phages, and strains of E. coli O157. ^a–iWithin same factors, means different letters differs (P < 0.05).