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. 2021 Feb 24;12:632937. doi: 10.3389/fimmu.2021.632937

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Copyright © 2021 Jasiński, Basak and Jedrzejczak

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antigens on multiple myeloma cells used as a target in CAR-T cell treatment. In the process of producing CAR-T cells, the main aim is to find the appropriate antigen which could be characterized by high expression levels on tumor cells and no expression on other healthy cells. The most known antigens used in the refractory/relapsed multiple myeloma CAR-T cell treatment are CD138, CD70, NKG2D, kappa light chain, CD19, SLAMF7/CS1, CD44v6, CD56, CD38, and BCMA. Created with BioRender.com.