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. 2021 Feb 24;12:632937. doi: 10.3389/fimmu.2021.632937

Figure 2.

Figure 2

Different constructs of CARs targeting BCMA. BCMA is an antigen that is the most studied in CAR-T cells for relapsed/refractory MM. In use are the following types of anti-BCMA CAR-T cells (A) first generation of anti-BCMA CAR-T cells which consists of scFv as a binding molecule, hinge, transmembrane molecule (CD8α), costimulatory molecule (CD28), and an activating domain (CD3ζ); (B) the main change in the second generation of anti-BCMA CAR-T cells named bb2121 (Indecabtagene Vicleucel) was a new costimulatory molecule (4-1BB/CD137); (C) bb21217 differed from bb2121 with a memory-like phenotype of the former; (D) LCAR38M/JNJ-4528 are identical cells possessing single variable fragment of heavy chains (llama) instead of scFv (mouse) as a binding domain which can bind two different epitopes of BCMA; (E) FHVH33-BCMA-T as a binding domain was used with a fully human heavy-chain variable domain; (F) in the JCAR125 (Orvacabtagene Autoleucel) binding domain consists of a human scFv and a transmembrane domain costimulatory molecule (CD28). Created with BioRender.com.