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. 2021 Feb 24;12:607966. doi: 10.3389/fimmu.2021.607966

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Copyright © 2021 Huang, Liu, Ye, Zhang, Mei, Zhu, Peng, Cai, Yan, Zeng, Nie, Sun, Hou and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Location and pair-wise linkage disequilibrium values of CTLA-4 and PD-1 SNPs in all study participants. (A) These five SNPs span 7 kb of CTLA-4 gene region. (B) These five SNPs of PD-1 gene region. Values of the pair-wise D' (×100) are shown in blocks (D' values of 1.0 are not presented). Haplotype blocks were estimated with the Haploview program.