Table 2.
Genotype and allele frequencies of CTLA-4 SNPs in the PSS patients and healthy controls.
| PSS n = 137 (%) | Control n = 139 (%) | p | P c | OR | 95% CI | |
|---|---|---|---|---|---|---|
| rs733618 | ||||||
| Genotype | ||||||
| TT | 71 (51.82) | 49 (35.25) | 0.005 | 0.082 | 1.81 | 1.12−2.92 |
| CT | 52 (37.96) | 66 (47.48) | 0.110 | 0.550 | 0.68 | 0.42−1.10 |
| CC | 14 (10.22) | 24 (17.27) | ||||
| Allele | ||||||
| T | 194 (70.80) | 164 (58.99) | 0.004 | 0.037 | 1.56 | 1.11−2.21 |
| C | 80 (29.20) | 114 (41.01) | ||||
| rs4553808 | ||||||
| Genotype | ||||||
| AA | 103 (75.18) | 112 (80.58) | 0.280 | 0.560 | 0.73 | 0.41−1.29 |
| AG | 28 (20.44) | 25 (17.99) | 0.605 | 0.726 | 1.17 | 0.67−2.13 |
| GG | 6 (4.38) | 2 (1.44) | ||||
| Allele | ||||||
| A | 234 (85.40) | 249 (89.57) | 0.139 | 0.278 | 0.68 | 0.41−1.12 |
| G | 40 (14.60) | 29 (10.43) | ||||
| rs5742909 | ||||||
| Genotype | ||||||
| CC | 104 (75.91) | 113 (81.29) | 0.275 | 0.635 | 0.71 | 0.40−1.26 |
| CT | 27 (19.71) | 24 (17.27) | 0.605 | 0.698 | 1.22 | 0.67−2.22 |
| TT | 6 (4.38) | 2 (1.44) | ||||
| Allele | ||||||
| C | 235 (85.44) | 250 (89.93) | 0.134 | 0.336 | 0.67 | 0.40−1.12 |
| T | 39 (14.23) | 28 (10.07) | ||||
| rs231775 | ||||||
| Genotype | ||||||
| AA | 30 (21.90) | 13 (9.35) | 0.004 | 0.122 | 2.72 | 1.35−5.47 |
| AG | 52 (37.96) | 58 (41.73) | 0.522 | 0.746 | 0.87 | 0.53−1.38 |
| GG | 55 (40.15) | 68 (48.92) | ||||
| Allele | ||||||
| A | 112 (40.88) | 84 (30.22) | 0.009 | 0.044 | 1.553 | 1.10−2.20 |
| G | 162 (59.12) | 194 (69.78) | ||||
| rs3087243 | ||||||
| Genotype | ||||||
| AA | 12 (8.76) | 4 (2.88) | 0.037 | 0.370 | 3.24 | 1.028−10.31 |
| AG | 48 (35.04) | 48 (34.53) | 0.930 | 0.930 | 1.02 | 0.62−1.68 |
| GG | 77 (56.20) | 87 (62.59) | ||||
| Allele | ||||||
| A | 72 (26.28) | 56 (20.14) | 0.088 | 0.293 | 1.36 | 0.92−2.02 |
| G | 202 (73.72) | 222 (79.86) |
Values in bold indicate significant differences. p value was calculated using χ2 test or Fisher’s exact test and corrected for multiple testing using the FDR method. PSS, Posner-Schlossman syndrome; Pc, corrected p value; OR, odds ratio; CI, confidence interval.