Table 1.
Baseline characteristics of patients and healthy controls included for skin suction blistering.
| Sample ID | Age (years) | Sex | Race | Diagnosis | Atopic comorbidities | EASI | Total serum IgE (kU/L) | Serum specific IgE (>0.35 kU/L) | Sample type | Age of AD disease remission (years) | scRNA-seq |
|---|---|---|---|---|---|---|---|---|---|---|---|
| AD20 | 22 | Male | Caucasian | Spontaneously healed AD | Allergic rhinoconjunctivitis, asthma | 0 | 46.2 | Mugwort pollen, dog dander, C. herbarum | Suction blister | 14 | GSM4932358 |
| AD21 | 45 | Female | Caucasian | Spontaneously healed AD | Allergic rhinoconjunctivitis | 0 | 39.7 | Timothy grass, birch pollen | Suction blister | 19 | GSM4932359 |
| AD24 | 41 | Male | Caucasian | Spontaneously healed AD | Allergic rhinoconjunctivitis, asthma | 0 | 281 | Timothy grass, rye, birch, mugwort pollen, D. pteronyssinus, cat dander, dog dander | Suction blister | 19 | GSM4932360 |
| AD25 | 41 | Female | Caucasian | Spontaneously healed AD | Allergic rhinoconjunctivitis | 0 | 428 | Mugwort pollen | Suction blister | 18 | GSM4932361 |
| HC1&2 | 42 | Female | Caucasian | Healthy control | None | n.a. | n.a. | n.a. | Suction blister | n.a. |
GSM4653863 GSM4653864 |
| HC3 | 47 | Female | Caucasian | Healthy control | None | n.a. | n.a. | n.a. | Suction blister | n.a. | GSM4653865 |
| HC4 | 49 | Female | Caucasian | Healthy control | None | n.a. | n.a. | n.a. | Suction blister | n.a. | GSM4653866 |
| HC5 | 39 | Male | Caucasian | Healthy control | None | n.a. | n.a. | n.a. | Suction blister | n.a. | GSM4653867 |
| HC6 | 40 | Male | Caucasian | Healthy control | None | n.a. | n.a. | n.a. | Suction blister | n.a. | n.a. |
| HC7 | 40 | Male | Caucasian | Healthy control | None | n.a. | n.a. | n.a. | Suction blister | n.a. | n.a. |
| HC8 | 28 | Female | Caucasian | Healthy control | None | n.a. | n.a. | n.a. | Suction blister | n.a. | n.a. |
| AD1 | 18 | Male | Caucasian | Atopic dermatitis | Allergic rhinitis | 34.2 | >5000 | D. pteronyssinus, D. farinae, plantain pollen | Suction blister | n.a. | GSM4653855 |
| AD2 | 19 | Female | Caucasian | Atopic dermatitis | None | 44.6 | 8.7 | None detected | Suction blister | n.a. | GSM4653856 |
| AD3 | 34 | Male | Caucasian | Atopic dermatitis | Allergic rhinoconjunctivitis, asthma | 44.7 | 1,138 | n.a. | Suction blister | n.a. | GSM4653857 |
| AD4 | 33 | Female | Caucasian | Atopic dermatitis | None | 5.5 | 180 | None detected | Suction blister | n.a. | GSM4653858 |
AD, Atopic dermatitis; EASI, Eczema Area and Severity Index; HC, Healthy control; n.a., not applicable. All samples were used for multiplex proteomics; HC6-8 were not used for scRNA-seq.