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. 2021 Mar 9;11:5493. doi: 10.1038/s41598-021-85009-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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S100A2 expression in the epidermis of patients with drug eruption and clinical manifestations. (A) Clinical manifestation of a patient with toxic epidermal necrolysis after exposure to celecoxib and (B) the expression of S100A2 in the epidermis. (C) Clinical manifestation of a patient with toxic epidermal necrolysis in response to phenytoin and (D) the expression of S100A2 in the epidermis. (E) Clinical manifestation of a patient with macular-type drug eruption after celecoxib treatment and (F) the expression of S100A2 in the epidermis.