Skip to main content
. 2021 Feb 24;12:583658. doi: 10.3389/fgene.2021.583658

FIGURE 1.

FIGURE 1

Assumptions of a Mendelian randomization analysis. Three core assumptions: (1) genetic variants must be strongly associated with the exposure (sleep duration); (2) genetic variants should be independent of any other confounders; (3) genetic variants influence risk of the outcome (AF and HF) only through the exposure.