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. 2021 Feb 24;12:632620. doi: 10.3389/fgene.2021.632620

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Copyright © 2021 Källberg, Vidman and Rydén.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adjusted Rand index for hierarchical clustering using the top 1000 ranked genes on the datasets KIRP (A), STAD (B), LGG (C), and BRCA (D). The vertical lines represent the first, second, and third quartiles of a random selection. The feature selection methods on the y-axis are: dip-test statistic (DIP), bimodality index (BI), bimodality coefficient (BC), variance reduction score (VRS), modified variance reduction score (mVRS), weighted variance reduction score (wVRS), entropy estimator (ENT), interquartile range (IQR), standard deviation (SD), mean value (M), third quartile (Q3), co-expression (CoEx1), modified co-expression (CoEx2), the positive control (PVAL), and the two negative controls ALL and RAND. The selection methods are ordered according to increasing performance.