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. 2021 Feb 24;12:632620. doi: 10.3389/fgene.2021.632620

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Copyright © 2021 Källberg, Vidman and Rydén.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adjusted Rand index for clustering based on 1000 selected genes with different proportions of the subtypes based on 100 random samplings of the KIRP (A), STAD (B), LGG (C), and BRCA (D) data. The figure shows results for unbalanced data with 25 (75) samples in the smaller (larger) subgroup and for balanced data sets with 50 samples in each subgroup. The selection methods on the x-axis are the dip-test statistic (DIP), bimodality index (BI), the modified variance reduction score (mVRS), and standard deviation (SD).