Table 3.
Association between Characteristics at the Time of Resolution and Relapse of Macular Edema among Eyes with Resolution of Uveitic Macular Edema in the Multicenter Uveitis Steroid Treatment Trial and Follow-up Study.
| Characteristics | Number events/number eyes at risk | Cumulative percent relapsed by 7 years (95% CI*) | HR† | 95% CI* | P-value |
|---|---|---|---|---|---|
| Overall | 59/177 | 43(32,51) | |||
| Age, years | |||||
| <57 | 43/117 | 48 (34,58) | 1.00 | ||
| ≥57 | 16/60 | 34 (17,47) | 0.64 | 0.35, 1.17 | 0.15 |
| Gender, number | |||||
| Women | 40/127 | 42 (30,53) | 1.00 | ||
| Men | 19/50 | 42 (25,55) | 1.31 | 0.73, 2.33 | 0.36 |
| Race/ethnicity | |||||
| White, non-Hispanic | 31/107 | 35 (22,46) | 1.00 | ||
| Black, non-Hispanic | 17/39 | 58 (35,73) | 1.80 | 1.03, 3.16 | 0.039 |
| Hispanic/Other | 11/31 | 45 (23,61) | 1.45 | 0.74, 2.83 | 0.28 |
| Uveitic anatomic class | |||||
| Intermediate uveitides | 30/87 | 43 (28,55) | 1.00 | ||
| Posterior/panuveitides | 29/90 | 41 (27,52) | 0.98 | 0.58, 1.64 | 0.92 |
| Macular edema diagnosis | |||||
| Prevalent (at baseline) | 40/116 | 40 (29,50) | 1.00 | ||
| Incident (during follow-up) | 19/61 | 51 (23,69) | 1.13 | 0.65, 1.99 | 0.66 |
| Uveitis duration, years | |||||
| ≤5 | 15/51 | 33 (17,46) | 1.00 | ||
| >5 | 42/122 | 47 (33,58) | 1.49 | 0.81, 2.72 | 0.20 |
| Uveitis activity | |||||
| Inactive | 43/138 | 40 (28,50) | 1.00 | ||
| Active | 15/38 | 49 (28,64) | 1.32 | 0.75, 2.31 | 0.33 |
| Central midpoint thickness on OCT‡, μm | |||||
| <200 | 36/127 | 38 (26,49) | 1.00 | ||
| ≥200 | 23/50 | 53 (34,66) | 2.02 | 1.21, 3.36 | 0.007 |
| OCT cystoid spaces | |||||
| Absent | 39/120 | 43 (29,54) | 1.00 | ||
| Present | 20/56 | 41 (25,54) | 1.30 | 0.75, 2.25 | 0.35 |
| Epiretinal membrane on OCT | |||||
| No | 25/78 | 39 (24,51) | 1.00 | ||
| Yes | 34/98 | 46 (31,58) | 1.25 | 0.73, 2.13 | 0.42 |
| Lens status | |||||
| Phakic | 12/43 | 29 (14,42) | 1.00 | ||
| Pseudophakic/aphakic | 47/134 | 48 (35,58) | 1.43 | 0.73, 2.80 | 0.30 |
| VA§ worse than 20/40 | |||||
| No | 34/100 | 43 (29,54) | 1.00 | ||
| Yes | 25/77 | 41 (26,53) | 0.99 | 0.60, 1.64 | 0.97 |
| VA 20/200 or worse | |||||
| No | 56/162 | 44 (33,54) | 1.00 | ||
| Yes | 3/15 | 22 (0,42) | 0.54 | 0.16, 1.82 | 0.32 |
*
95% CI = 95% confidence interval.
†
HR = hazard ratio. HR’s > 1.00 associated with faster relapse.
‡
OCT = optical coherence tomogram. Numbers from different machines normalized to Zeiss Stratus scale.
§
VA = visual acuity.