Fig. 15.

Myelination is not affected by early treatments of cisplatin. The early treatment of cisplatin did not result in significant differences in the myelination of axons in the osseous spiral laminae of the cochlea. a Electron micrograph of axons in the basal turn of the cochlea after an early treatment of cisplatin. Myelination appears regular and without noticeable pathologies. However, note the absence of mitochondria in the axon marked with a red asterisk. The absence of mitochondria after a 4 × 1 treatment of cisplatin occurred more frequently in the base than the middle or apex. b Electron micrograph of an axon in the apex after an early treatment of cisplatin with normal myelination. c Electron micrograph of an axon in the base after a 4 × 2 treatment of cisplatin. Note the formation of a large vacuole and separation of the cytoplasm from the myelin sheath (red asterisk). d Electron micrograph of an axon in the apex after a 4 × 2 treatment of cisplatin. Note the splitting and ballooning within the myelin (red asterisk). e Electron micrograph of an axon in the base after a 4 × 3 treatment of cisplatin. The axon is malformed, and vacuoles are present (red asterisks). f Electron micrograph of an axon in the apex after a 4 × 3 treatment of cisplatin. The mitochondria in the axon are severely damaged as it is very swollen, and the cristae are largely absent (larger red asterisks). There is also a vacuole present (smaller red asterisk). Scale bars = 500 nm