Fig. 7.

Changes of ABR wave 1 and DPOAE amplitudes after cisplatin 4 × 2 treatment. ABR wave 1 amplitudes were determined at the frequencies of 10 kHz (a), 20 kHz (b), 28 kHz (c), and 40 kHz (d) before (“Saline-baseline” and “Cisplatin-baseline”) and after (“Saline-C2” and “Cisplatin-C2”) the 4 × 2 protocol. Analyses revealed that the cisplatin-treated group (n = 10) experienced significant wave 1 amplitude decreases at 40 kHz, while the saline group (n = 6) did not. e–h DPOAE data revealed a similar pattern, with the cisplatin group presenting significant decreases in amplitude at 40 kHz. *p < 0.05, **p < 0.01, and ***p < 0.001. Data shown are the means ± 1 SEM