Table 1.

Baseline characteristics

	Control group N = 89	Diuretic group N = 77
Age	66 [60–74]	66 [58–72]
Sex ratio F/M	28(31.5%)/61(68.6%)	16(20.8%)/61(79.2%)
SAPS II	53 [45–59]	52 [41–58]
SOFA baseline	7 [5–10]	8 [6–10]
SOFA at randomization	4 [2–6]	4 [3–5]
Height (cm)	169 [163–175]	171 [163–175]
Weight at baseline (kg)	76 [64–85]	82 [68–92]
Weight at randomization (kg)	84 [75–97]	88.5 [73–99]
MV before randomization (days)	5 [4–8]	6 [4–8]
BMI	25.5 [22.6–29.2]	28.4 [25.5–34.5]
Hypertension	13 (14.6%)	5 (6.5%)
Chronic respiratory disease	10 (11.2%)	5 (6.5%)
Chronic kidney disease	3 (3.4%)	1 (1.3%)
Use of diuretics	11 (12.4%)	8 (10.4%)
Diabetes mellitus	9 (10.1%)	11 (14.3%)
Active smoking	21 (23.6%)	14 (18.2%)
Admission
Sepsis/septic shock	28 (31.4%)	21 (27.2%)
Acute respiratory failure	42 (47.2%)	33 (42.9%)
Trauma	7 (7.9%)	6 (7.8%)
Hemorrhagic shock	5 (5.6%)	4 (5.2%)
Elective surgery	1 (1.1%)	4 (5.2%)
Misc	6 (6.8%)	9 (11.7%)
RRT/AKI before randomization	27 (30.3%)	21 (27.3%)

N (%) for qualitative variable and median [Q1–Q3] for quantitative variable

BMI body mass index, RRT renal-replacement therapy, MV mechanical ventilation, AKI acute kidney injury defined as a blood level of creatinine ≥ 180 μmol L⁻¹