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. 2021 Mar 10;7(1):89–100. doi: 10.1007/s41030-021-00148-7
Particulate matter, NO2, and O3 are the culprit pollutants leading to respiratory diseases.
HP: The proportion of HP cases increased with higher levels of air pollution in several Indian cities.
IPF: Air pollution has been associated with lower FVC, accelerated decline of FVC, and acute exacerbations in patients with IPF.
ILA: Also associated with increased risk of having ILA in both adults and children.
Possible mechanism: Air pollution → oxidant stress, inflammatory response and telomere shortening → fibrotic pathway.
Exposome should be evaluated to ascertain the cause of pulmonary fibrosis.
Patients with ILD should avoid strenuous exercise during bad-quality air days and use facemasks.