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. 2021 Feb 24;12:620433. doi: 10.3389/fphar.2021.620433

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Copyright © 2021 Xiong, Chang, Hao, Zhang, Yang, Wang, Liu, Wang, Mu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of long term-UUO and treatment of eplerenone (EPL) on renal histology, fibrosis, and function of the contralateral kidneys. Kidney sections from all groups were stained with HE for morphology changing (A), Masson's Trichrome (Masson) for fibrosis (B), and Sirius red for collagen deposition (C). Images are representative for n = 12 rats each group. (D) BUN and Scr in serum were evaluated for renal function. Renal scores and quantification data are presented as mean ± SEM, n = 6. *p < 0.05 vs. the sham, #p < 0.05 vs. the UUO.