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. 2021 Feb 24;12:639655. doi: 10.3389/fmicb.2021.639655

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Copyright © 2021 de Mello, Fernandes, Furtado, dos Santos, dos Santos, Ribeiro, Raphael, Nogueira, da Cruz, Rocha, Manso, Pelajo-Machado and Bonaldo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological features in AG129 mouse brain after the infection with the ZIKV Rio-U1 (Parental) and the Infectious cDNA Clone (IC.RioU1). Karyorrhexis in the cortex of IC.RioU1 (A) and Parental (B) infected animal. Nuclear pyknosis and karyorrhexis in the hippocampus (C) and bordering the choroid plexus (D). Brain hemorrhage foci (E). Perivascular cuffs with a neutrophilic predominance (F). The images are representative of IC.RioU1 (A,C) and Rio-U1 (B,D–F) infection. Black arrows indicate the histopathological features observed in each panel (A–F). The brain sections were stained with hematoxylin and eosin. Data are representative of two independent experiments.