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. 2021 Mar 5;16:1913–1926. doi: 10.2147/IJN.S297933

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© 2021 Si et al.

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LIP-PFH nanoparticles triggered by LIFU activated the immune response of T-cells in blood and spleen. (A–C) Dynamic changes of CD4⁺T, CD8⁺T and CD8⁺PD-1⁺T cells in the peripheral blood; (D) changes of IFN-γ released by peripheral blood; (E, F) the proportion of CD3⁺CD4⁺T and CD3⁺CD8⁺T cells in spleens; (G) the ratio of CD8⁺PD-1⁺T-cells in CD3⁺T cells; n=3, *p<0.05, **p<0.01, ***p<0.001.