Table 1.
Demographic and clinical features of IgAN patients.
| Characteristics | All (n = 1071) | Groups | ||||
|---|---|---|---|---|---|---|
| C1q-positive (n = 145) | Unmatched cohort C1q-negative (n = 926) |
P value | Matched Cohort (1:4 PSM) C1q-negative (n = 580) |
P value | ||
| Clinical | ||||||
| Age (year) | 33.80 ± 10.96 | 33.18 ± 10.94 | 33.89 ± 10.97 | 0.466 | 33.99 ± 11.24 | 0.431 |
| Male (%) | 464(43.32) | 57(39.31) | 407(43.95) | 0.290 | 266 (45.86) | 0.156 |
| SBP (mmHg) | 130.63 ± 20.27 | 133.50 ± 21.36 | 130.18 ± 20.07 | 0.066 | 130.17 ± 19.38 | 0.070 |
| DBP (mmHg) | 83.58 ± 14.21 | 85.78 ± 14.92 | 83.24 ± 14.07 | 0.045 | 83.43 ± 14.21 | 0.078 |
| MAP (mmHg) | 99.26 ± 15.35 | 101.69 ± 16.45 | 98.88 ± 15.14 | 0.041 | 99.01 ± 15.04 | 0.060 |
| Hypertension (%) | 374 (34.92) | 58 (40.00) | 316 (34.13) | 0.168 | 198 (34.14) | 0.186 |
| Serum creatinine (µmol/L) | 100.76 ± 53.06 | 107.60 ± 53.70 | 99.69 ± 52.90 | 0.095 | 99.88 ± 53.49 | 0.121 |
| eGFR (ml/min per 1.73 m2) | 87.48 ± 49.72 | 81.03 ± 34.84 | 88.49 ± 51.60 | 0.027 | 87.26 ± 32.87 | 0.044 |
| Urinary Protein (g/24 h) | 2.67 ± 2.99 | 3.27 ± 2.74 | 2.58 ± 3.02 | 0.010 | 2.78 ± 3.22 | 0.092 |
| Serum albumin (g/L) | 38.15 ± 12.51 | 35.90 ± 7.96 | 38.50 ± 13.05 | 0.020 | 38.22 ± 15.62 | 0.084 |
| Uric acid (µmol/L) | 378.79 ± 158.08 | 377.05 ± 106.72 | 379.06 ± 164.72 | 0.887 | 380.11 ± 190.48 | 0.852 |
| CKD stage | 0.049 | 380.11 ± 190.48 | 0.059 | |||
| Stage 1 | 531 (49.58) | 63 (43.45) | 468 (50.54) | 294 (50.69) | ||
| Stage 2 | 267 (24.93) | 32 (22.07) | 235 (25.38) | 148 (25.52) | ||
| Stage 3 | 219 (20.45) | 42 (28.97) | 177 (19.11) | 110 (18.97) | ||
| Stage 4 | 54 (5.04) | 8 (5.52) | 46 (4.97) | 28 (4.83) | ||
| Treatment | 0.043 | 0.951 | ||||
| SC | 411 (38.38) | 42 (28.97) | 369 (39.85) | 168 (28.97) | ||
| CS | 390 (36.41) | 61 (42.07) | 329 (35.53) | 251 (43.28) | ||
| IT | 270 (25.21) | 42 (28.97) | 228 (24.62) | 161 (27.76) | ||
Values for categorical variables are given as number (percentage); values for continuous variables are given as mean ± standard deviation or median (interquartile range).
SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, SC supportive care group, CS corticosteroids, IT immunosuppressive therapy.