Table 2.
Pathologic features of IgAN patients.
| Characteristics | All (n = 1071) | Groups | ||||
|---|---|---|---|---|---|---|
| C1q-positive (n = 145) | Unmatched cohort C1q-negative (n = 926) |
P value | Matched Cohort (1:4 PSM) C1q-negative (n = 580) |
P value | ||
| Pathologic | ||||||
| Oxford classification | ||||||
| M1 | 805 (75.16) | 118 (81.38) | 687 (74.19) | 0.062 | 441 (76.03) | 0.171 |
| E1 | 56 (5.23) | 19 (13.10) | 37 (4.00) | < 0.001 | 28 (4.83) | < 0.001 |
| S | 542 (50.61) | 66 (45.52) | 476 (51.40) | 0.187 | 307 (52.93) | 0.110 |
| T0 | 836 (78.06) | 102 (70.34) | 734 (79.27) | 0.007 | 456 (78.62) | 0.044 |
| T1 | 190 (17.74) | 39 (26.90) | 151(16.31) | 103 (17.76) | ||
| T2 | 45 (4.20) | 4 (2.76) | 41 (4.43) | 21 (3.62) | ||
| C0 | 762 (71.15) | 92 (63.45) | 670 (72.35) | < 0.001 | 407 (70.17) | 0.004 |
| C1 | 243 (22.69) | 33 (22.76) | 210 (22.68) | 140 (24.14) | ||
| C2 | 66 (6.16) | 20 (13.79) | 46 (4.97) | 33 (5.69) | ||
| IgA deposition | 0.530 | 0.440 | ||||
| 1 + | 116 (10.83) | 20 (13.79) | 96 (10.37) | 58 (10.00) | ||
| 2 + | 495 (46.22) | 62 (42.76) | 433 (46.76) | 276 (47.59) | ||
| 3 + | 454 (42.39) | 62 (42.76) | 392 (42.33) | 244 (42.07) | ||
| 4 + | 6 (0.56%) | 1 (0.69) | 5 (0.54) | 2 (0.34) | ||
| IgG deposition | 97 (9.06) | 32 (22.07) | 65 (7.02) | < 0.001 | 40 (6.90) | < 0.001 |
| IgM deposition | 521 (48.65) | 127 (87.59) | 394 (42.55) | < 0.001 | 251 (43.28) | < 0.001 |
| C3 deposition | 876 (81.79) | 124 (85.52) | 752 (81.21) | 0.211 | 458 (78.97) | 0.076 |
| C4 deposition | 52 (4.86) | 33 (22.76) | 19 (2.05) | < 0.001 | 11 (1.90) | < 0.001 |
Values for categorical variables are given as number (percentage); values for continuous variables are given as mean ± standard deviation or median (interquartile range).
M mesangial proliferation, E endocapillary proliferation, S segmental sclerosis, T tubular atrophy/interstitial fibrosis, C crescents.