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. 2021 Mar 9;11:5511. doi: 10.1038/s41598-021-84765-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Frequency of B cell subsets based on CD24 and CD27 or CD27 and CD38 markers expression in peripheral blood from CCD patients and non-infected donors. (a,b) Representative dot plots from a non-infected donor showing the gating strategy used to determine the subsets within total B cells according to the combined expression of CD24 and CD27 or CD27 and CD38. (c,d) Frequency of B cell subsets in CCD patients (G0, G1) and non-infected donors (NI). Each dot represents data from one subject; inside G1 group, solid circles correspond to K1 patients, hollow triangle to K2 patient and hollow square to K3 patient. Boxes and whiskers show median value and interquartile range.