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. 2021 Mar 9;11:5511. doi: 10.1038/s41598-021-84765-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phenotypic distribution of B10 cells according to CD27, CD27-CD24 and CD27-CD38 expression in CCD patients and non-infected donors. (a) Histograms showing the gating strategy used to determine CD27⁻ (naïve) and CD27⁺ (memory) populations within B10 cells in PIB stimulated PBMC. One representative non-infected donor is illustrated. (b) Frequency of CD27⁻ and CD27⁺ B10 cells in CCD patients (G0, G1) and non-infected donors (NI). (c,d) Representative dot plots from a non-infected donor showing gating strategy used to determine the subsets within total B10 cells based on the combine expression of CD24 and CD27 or CD27 and CD38 in PIB stimulated PBMC. (e,f) Frequency of B10 cell subsets within CD24-CD27 and CD27-CD38 subpopulations in CCD patients (G0 G1) and non-infected donors (NI). Each dot represents data from one subject; inside G1 group, solid circles correspond to K1 patients, hollow triangle to K2 patient and hollow square to K3 patient. Boxes and whiskers show median value and interquartile range. Statistically significant differences among groups are indicated (*p < 0.05).