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. 2021 Mar 9;12:1534. doi: 10.1038/s41467-021-21413-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a B cells subsets P1 (CD19⁺CD24^hiCD38^hiIgD⁺), P2 (CD19⁺CD27⁺CD39^hiIgD⁺), P3 (CD19⁺CD27⁻CD39⁺IgD⁺), P4 (CD19⁺CD27⁺CD39^hiIgD⁻), P5 (CD19⁺CD27⁻CD39⁻IgD⁺), and P6 (CD19⁺CD27⁻CD39⁺IgD⁻) B cells in the blood of healthy subjects. Data generated with cells from healthy subjects (n = 5) were combined. b A t-SNE plot, showing the distribution of the six B cell populations (P1 to P6). t-SNE plots were made on CD19⁺ B cells using cell surface markers, including IgD, CD24, CD27, CD38, CD39, with iteration 1000, perplexity 30, and learning rate (eta) 1564. c Cell surface expression of IgD, IgM, CD1c, CD1d, CD5, CD9, CD10, CD21, CD23, CD24, CD25, CD27, CD38, CD39, CD43, CCD71, CD73, CD147, CXCR3, TIM-1, CD11a, CD11b, CD11c, integrin α1, integrin α4, integrin β1, and integrin β7 on P1 (red), P2 (light blue), P3 (pink), P4 (light green), P5 (army green), and P6 (violet) B cells. Data generated with cells from healthy subjects (n = 5) were combined.