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. 2021 Feb 24;11:629640. doi: 10.3389/fonc.2021.629640

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Copyright © 2021 Lu, Li, Ding, Wang, Tang, Liu, Xu, Zhou, Sun, Wang and Ding

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of UCHL1 in fatty acid synthesis in BC cells. (A, B) Cell viability curves and IC50 values of MCF-7 and DOX-resistant MCF-7/DOX cells treated with DOX are shown (n = 3). Western blot analysis of UCHL1 (C) and real-time PCR analysis of lipogenesis-associated genes (D) in MCF-7 and MCF-7/DOX cells are shown and were analyzed by Mann-Whitney test (n = 3). The level of fatty acids in MCF-7 and MCF-7/DOX cells (E) and MCF-7/DOX cells in the presence of 5 μM LDN or DMSO (F). (G, H) Cell viability curves and IC50 values of MCF-7/DOX cells treated with DOX in the presence of 5 μM LDN or DMSO are shown (n = 3). ^* p < 0.05, ^** p < 0.01.