Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 24;11:631991. doi: 10.3389/fonc.2021.631991

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Ge, Tian, Pei, Tan and Pei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Profiles of pathways through which extracellular matrix stiffness affects glucose metabolism. Extracellular matrix stiffness affects glucose metabolism in the following seven pathways: (i) YAP/TAZ pathway; (ii) TXNIP pathway; (iii) Rho/Rock-actin cytoskeleton pathway; (iv) Rho/Rock-PTEN pathway; (v) integrin-FAK-PI3K-Akt pathway; (vi) GSK3 pathway; and (vii) AMPK pathway. The effects of extracellular matrix stiffness on cellular glucose metabolism can ultimately be summarized as follows: (i) Changes in the number of glucose transport proteins in the cell membrane; (ii) Alteration of glycolytic enzyme activity; (iii) Alteration of glycogen synthase activity; (iv) Expression of gluconeogenic genes; (v) Enhancement of the pentose phosphate pathway; and (vi) Endocytosis of cells.