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. 2021 Feb 24;11:631991. doi: 10.3389/fonc.2021.631991

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Copyright © 2021 Ge, Tian, Pei, Tan and Pei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Profiles of pathways through which extracellular matrix stiffness affects lipid metabolism. Extracellular matrix stiffness affects lipid metabolism in the following five pathways: (i) integrin-FAK-PI3K-Akt pathway; (ii) YAP/TAZ pathway; (iii) AMPK pathway; (iv) Rho/Rock-actin cytoskeleton pathway; and (v) TXNIP pathway. The effects of extracellular matrix stiffness on cellular lipid metabolism can be described as upregulation of SREBP, LDLR, LPL and CD36.