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. 2021 Feb 24;11:572585. doi: 10.3389/fonc.2021.572585

Figure 1.

Figure 1

(A) Microarray results indicating that MIR22HG expression in MHCC97H cells increased significantly after irradiation. (B) Kaplan-Meier curves of the overall survival. The P-value was computed using the log-rank test. (C) mRNA expression of MIR22HG and miR-22-5p in tumor (n = 16) and non-tumor (n = 16) tissue. (D) miR-22-5p expression in blood samples of healthy individuals and patients with HCC before and after radiotherapy. (E, F) mRNA expression of MIR22HG and miR-22-5p in HCC cells Huh7, HepG2, Hep3B, BEL-7402, MHCC97H, and MHCC97L and in the human normal liver cell L02. *Compared with the L02 group. Mean ± SD (n = 3 independent experiments). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.