Figure 1.

The itch matrix categorized into three itch matrixes. First itch matrix consisted of primary and secondary sensorimotor cortex (SI and SII, respectively), the parietal/central operculum, and the posterior insular cortex (pIC) (here presented in brown, this matrix is also presented in Figure 2A). The second itch matrix consisting of anterior singular cortex (ACC), anterior part of the middle cingulate cortex (aMCC), anterior part of the insular cortex (aIC), amygdala, striatum and hippocampus (here presented in blue, this matrix is also presented in Figure 2B). The third matrix contains prefrontal cortex, posterior part of the middle cingulate cortex (pMCC), and posterior cingulate cortex (PCC) (here presented in red, this matrix is also presented in Figure 2C).