Figure 2.

Proposals for itch matrixes (X,Y,Z denotes the location of the corresponding slice in Montreal Neurological Institute (MNI) coordinate system). (A) Elements of the first matrix contributing to encoding of the recognition, localization, and intensity of itch. Primary sensorimotor cortex is presented in Blue, parietal operculum in Green, and posterior insular cortex in Red (Regions have been extracted from Automated Anatomical Labeling and Harvard-Oxford atlases). (B) The second matrix itch processing matrix consenting of anterior cingulate cortex (Blue), anterior insular cortex (Red), amygdala (Green) and hippocampus (Violet). This matrix is in charge of affective and motivational aspects of itch. (C) The third matrix consists of frontal cortex (Blue), middle cingulate cortex (Red), and posterior cingulate cortex (Green), and it is involved in the interpretation of the cognitive meaning of itch.