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. 2021 Feb 24;8:636904. doi: 10.3389/fmed.2021.636904

Table 2.

Results of the all the papers studied the central mechanism of itch.

Parts of which matrix 1 1 1/2 3 2 3 3 3 2 1 2 2 2 2
Regions Primary somatosensory cortex (BA 1, 2, 3) Somatosensory associated/parietal cortex (BA 5, 7) Primary motor cortex (BA 4) Pre- motor and supplementary motor cortex (BA 6) Cerebellum Insular cortex (BA 13, 16) Posterior cingulate cortex (BA 23,31) Anterior cingulate cortex (BA 24, 32, 33) Prefrontal cortex (BA 9) Frontopolar and orbifrontal area (BA 8, 10, 11, 12) Inferior and dorsolateral prefrontal cortex (BA 44, 45, 46, 47) Temporal gyrus (BA 20, 21, 22, 38) + fusiform Prietal pole/Wernicke's area (BA 39, 40) Inferior parietal, supramarginal Thalamus Basal ganglia Secondary somatosensory cortex (BA 40, 43) OPC Precuneus (BA 7, 31) Putamen Visual association gyrus (BA 17, 18, 19) ocipital Anterior entorhinal cortex (BA 34) Hippocampus Parahippocampal gyrus Ventral tegmental area cum om Ventral tegmental area Raphé nucleus Red Nucleus PAG Substantia nigra Clastrum Midbrain Amygdala Brain steem Lentiform nucleus Pons
# Author
1 (3) B B C B
2 Darsow et al. (4) B C B C C C C
3 Darsow et al. (4) B B B C C B C C C C B I C
4 Drzezga et al., (5)
5 Mochizuki et al. (6) I I C B I C
6 Walter et al. (7) C C B C
7 Herde et al. (8) C C B B B B (m) B C B B B B B
8 Leknes et al. (9) B B B I
9 Leknes et al. (9) C C C B B C B B
10 Mochizuki et al. (10) I B C C I
11 Mochizuki et al. (10) I B C I
12 Valet et al. (11) B- C- I C I- B- B B B
13 Valet et al. (11) C- I B I- B
14 Schneider et al. (12) C C C C I
15 Schneider et al. (12) B B I I B C C C I
16 Schneider et al. (12) C I
17 Yosipovitch et al. (13) B- B- B,B- B B B- I,B- I,B- B B B B B-
18 Ishiuji et al. (14) B B I B B B B B I C B C B C
19 Ishiuji et al. (14) C C C C C
20 Ishiuji et al. (14) C C C
21 Mochizuki et al. (15) C I B I I C B B B C
22 Mochizuki et al. (15) B B C
23 Vierow et al. (16) B B B B B B B B B I B B
24 Vierow et al. (16) B B B B B B B B B B B B B
25 Pfab et al. (17) B- B- B- B- B B B- B I
26 Pfab et al. (17) B- B- B- B B- B- B
27 Bergeret et al. (18) I I I C I I B C B
28 Bergeret et al. (18) C I
29 Holle et al. (19) L L L B B L B B
30 Holle et al. (19) L L L
31 Kleyn et al. (20) I B B C
32 Kleyn et al. (20) C B B
33 Papoiu et al. (21)
34 Papoiu et al. (21) C C B C B B C B B B B C B C C
35 Papoiu et al. (21) B C B C I C
36 Papoiu et al. (21) L B B L L B L B R
37 Papoiu et al. (21) L B L L L B L
38 Papoiu et al. (22) I B C C B I I I B C C B B B B C
39 Papoiu et al. (22) C C I I I
40 Stumpf et al. (23) B B C C B I B C C, I-
41 Stumpf et al. (23) I C- C B I
42 Napadow et al. (24) I B C C C B B
43 Napadow et al. (24) B B C C I C C C C C C
44 Desbordes et al. (25) R L
45 Desbordes et al. (25) L L L L
46 Desbordes et al. (25) L L B L (42)
47 Desbordes et al. (25) R L L R
48 Desbordes et al. (25) R R R
49 Desbordes et al. (25) L L
50 Desbordes et al. (25) L R
51 Mochizuki et al. (26) L R R B B R L B B B B B
52 Mochizuki et al. (26) B B B B B B B B B B B B B
53 Mochizuki et al. (26) B B L L B R L B L L
54 Mochizuki et al. (26) B B L L B L B B
55 Mochizuki et al. (26) B B R B R B B
56 Papoiu et al. (27) I I B L B B B B B B I C I B B B I
57 Papoiu et al. (27) C I B C I B C I C C B C C I C
58 Kim et al. (28) R R R L L
59 Kim et al. (28) B R L L B L R R L
60 Kim et al. (28) B B B
61 Mochizuki et al. (29) B B B B I B B I B I B B B C C
62 Mochizuki et al. (29) C B C B B I I B C B B C I B C
63 Mochizuki et al. (29) C,I- B,I- B- I- C B C I- C
64 Mochizuki et al. (29) C B C I B B B B B B B I B C B B
65 Mochizuki et al. (29) B B B B I I I C B B B
66 Mochizuki et al. (29) I I C B C C,I- I C I C I- C I-
67 Napadow et al. (30) C I C
68 Papoiu et al. (31) I B
69 Papoiu et al. (31) C B I C I I C B B I C I I
70 Vierow et al. (32) B I- B B B,C- B B B C B- B-
71 Vierow et al. (32) B I- B B B B B B C C-
72 Vierow et al. (32) B I- B B B B B C B C C- B-
73 Vierow et al. (32) B I- B B I B B C B C C-
74 Schut et al. (33) B I C
75 Schut et al. (33) I I I I
76 Stumpf et al. (34) B- C C B- B- I- I I- I B- C- I- I- B-
77 van de Sand et al. (35) C I I- C I,C- C B
78 van de Sand et al. (35) C- C I I,C- C I I
79 Wang et al. (36) R R
80 Wang et al. (36) R-
81 Wang et al. (36) L-
82 Wang et al. (37) B
83 Wang et al. (37) B B B
84 Wang et al. (37) B B R R R B R
85 Wang et al. (37) R- R- R- R-
86 Wang et al. (37) B- L- R- L- L- L-
87 Min et al. (38) L L
88 Min et al. (38) L
89 Min et al. (38) C L C
90 Mochizuki et al. (39) C C C B L B B B B B B B

If laterality applicable: B, Bilateral; C, Contralateral to stimulus; I, Ipsilateral to stimulus. If laterality not applicable: B, Bilateral; L, Left; R, Right.

When only the peak locations were reported the sprout022 tool (Dept. of Radiology and Biomedical Imaging, Yale School of Medicine) was used to identify the regions.