TABLE 2.
Etest minimum inhibitory concentrations (median and range) of ceftriaxone sodium and PPIX-MED alone and in combination.
MIC (μg/ml) |
FICI▲ | Interpretation | ||||
MICA | MICA(with B) | MICB | MICB(with A) | |||
MRSA | 128 μg/ml | 64 μg/ml | 16 μM | 8 μM | 1 | Indifference |
P. aeruginosa | 32 μg/ml | 16 μg/ml | 32 μM | 4 μM | 0.625 | Indifference |
E. coli | 64 μg/ml | 16 μg/ml | 32 μM | 16 μM | 0.75 | Indifference |
MICA, ceftriaxone sodium; MICB, PPIX-MED; MICA(with B), ceftriaxone sodium with PPIX-MED; MICB(with A), PPIX-MED with ceftriaxone sodium. ▲ The fractional inhibitory concentration index (FICI) data were interpreted using the following criteria: synergistic effect, FICI ≤ 0.5; additive effect, FICI 0.5–1.0; irrelevant effect, FICI 1.0–2.0; and antagonistic effect, FICI ≥ 2.0.