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. 2021 Feb 24;12:622410. doi: 10.3389/fmicb.2021.622410

TABLE 2.

Etest minimum inhibitory concentrations (median and range) of ceftriaxone sodium and PPIX-MED alone and in combination.

MIC (μg/ml)
FICI Interpretation
MICA MICA(with B) MICB MICB(with A)
MRSA 128 μg/ml 64 μg/ml 16 μM 8 μM 1 Indifference
P. aeruginosa 32 μg/ml 16 μg/ml 32 μM 4 μM 0.625 Indifference
E. coli 64 μg/ml 16 μg/ml 32 μM 16 μM 0.75 Indifference

MICA, ceftriaxone sodium; MICB, PPIX-MED; MICA(with B), ceftriaxone sodium with PPIX-MED; MICB(with A), PPIX-MED with ceftriaxone sodium. The fractional inhibitory concentration index (FICI) data were interpreted using the following criteria: synergistic effect, FICI ≤ 0.5; additive effect, FICI 0.5–1.0; irrelevant effect, FICI 1.0–2.0; and antagonistic effect, FICI ≥ 2.0.