TABLE 3.
Percentage of ‡HBV DNA Clearance at each time point.
| All subjects | GG | GA | p# | Odds ratio (95%CI) | |
|---|---|---|---|---|---|
| 12-weeks (%) | 73/136 (53.68) | 27/68 (39.71) | 46/68 (67.65) | 0.002 | 1.86 (1.26, 2.76) |
| ETV (%) | 60/110 (54.55) | 20/55 (36.36) | 40/55 (72.73) | <0.001 | 2.33 (1.45, 3.75) |
| TDF (%) | 13/26 (50) | 7/13 (53.85) | 6/13 (46.15) | 1.000 | 0.74 (0.16, 3.43) |
| 24-weeks (%) | 96/136 (70.59) | 43/68 (63.24) | 53/68 (77.94) | 0.090 | 2.05 (0.97, 4.38) |
| ETV (%) | 80/110 (72.73) | 35/55 (63.64) | 45/55 (81.82) | 0.053 | 2.57 (1.07, 6.19) |
| TDF (%) | 16/26 (61.54) | 8/13 (61.54) | 8/13 (61.54) | 1.000 | 1.00 (0.21, 4.86) |
| 48-weeks (%) | 112/136 (82.35) | 53/68 (77.94) | 59/68 (86.76) | 0.261 | 1.86 (0.75, 4.59) |
| ETV (%) | 91/110 (82.73) | 43/55 (78.18) | 48/55 (87.27) | 0.313 | 1.91 (0.69, 5.30) |
| TDF (%) | 21/26 (80.77) | 10/13 (76.92) | 11/13 (84.62) | 1.000 | 1.65 (0.23, 12.00) |
| 96-weeks (%) | 129/136 (94.85) | 63/68 (92.65) | 66/68 (97.06) | 0.441 | 1.68 (0.52, 5.42) |
| ETV (%) | 104/110 (94.55) | 51/55 (92.73) | 53/55 (96.36) | 0.742 | 1.56 (0.42, 5.87) |
| TDF (%) | 25/26 (96.15) | 12/13 (92.31) | 13/13 (100) | 1.000 | 2.18 (0.17, 27.56) |
#p - value between GG and GA group. Significant p-value in bold (threshold p < 0.05).
‡HBV DNA clearance defined as an undetectable HBV DNA load (<20 IU/ml) in peripheral blood
Log-rank test (p = 0.0198)