Table 3.
Registered Randomized Clinical Trials involving different sources of SCs—apart from Bone Marrow Derived Stem Cells—for POF/POI patients.
| Regenerative factor | Study population | Inclusion criteria | Number of clinical trial | Status |
|---|---|---|---|---|
| Human umbilical cord mesenchymal stem cells (hucMSCs) | 12 patients with POF | -Diagnostic criteria of ESRHE -No hormonotherapy within 3 months |
NCT03816852 | Suspended |
| Human umbilical cord mesenchymal stem cells (hUCMSCs) and human cord blood mononuclear cells (hCBMNCs) | 40 patients with POF | -Age: 18–39 -Clinical diagnosis of POF -Currently receiving Hormone Replacement Therapy |
NCT01742533 | Unknown |
| Human Embryonic Stem Cell Derived Mesenchymal Stem Cell (MSC)-Like Cells | 18 patients with POF | -Age >40 -Have established regular menstrual cycle, oligomenorrhea/amenorrhea ≥4 months -FSH >25 IU/ml -Bilateral ovaries visible by ultrasound -Fertility requirement and sperms in couple |
NCT03877471 | Recruiting |
| Autologous very small embryonic-like stem cells (VSELs) | Estimated POF population not shown | -Clinical diagnosis of POF -Abnormal sex hormone levels |
NCT03985462 | Withdrawn |
| Human Adipose Derived Mesenchymal Stromal Cells | 9 patients with POF | -Age: 20–39 -FSH >20 |
NCT02603744 | Unknown |
| Human Adipose derived stem cells (ADSC) | 4 patients with POF | -Age: 20–39 -Clinical diagnosis of POF -Lack of response to drug treatment -Willing to receive follow-up -Willing to conceive a baby |
NCT01853501 | Unknown |
| Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) | 320 patients with POF | -Age: 20–40 -Clinical diagnosis of POF -Fertility requirement and sperms in couple |
NCT03033277 | Unknown |
| Human Umbilical Cord-derived Mesenchymal Stem Cells (hUC-MSCs) | 23 patients with POF | -Age: 20–39 -Clinical diagnosis of POF -Lack of response to drug treatment |
NCT02644447 | Completed |
| Ovarian Stem Cells | 11 patients with POF | -Age: 20–39 -Clinical diagnosis of POF, POI, or DOR -Early follicular phase FSH >15 IU/L -AMH <0.16 ng/ml or below the level of detection for the assay used -Undergoing ovarian biopsy by laparoscopy or clinically indicated abdominal surgery that provides access to the ovaries -Early follicular phase FSH >15 IU/L -AMH <0.16 ng/ml or below the level of detection for the assay used |
NCT01702935 | Completed |
POF, premature ovarian failure; ESRHE, European Society of Human Reproduction and Embryology; FSH, follicle stimulating hormone; POI, premature ovarian insufficiency; DOR, diminished-ovarian reserve.