Table 2.

Summary of complement protein single nucleotide polymorphisms (SNPs) in hepatocellular carcinoma (HCC).

Complement protein	SNP	Biological function	Reference
C2	rs9267665	Increases the risk of HCC and Liver Cirrhosis (LC). Alters transcriptional activity of C2	Clifford et al. (192)
	rs2647073	Associated with HCC and LC
	rs3997872	Associated with HCC but not with LC
	rs10947223	Protects from HCC. Alters transcriptional activity of C2	Namgoong et al. (193)
	rs9279450	Protective effects against HCC and chronic hepatitis B (CHB)
CR1	rs3811381	Increases risk of HBV-HCC and HBV-Chronic hepatitis B in males	Luo et al. (231)
	rs2274567	Increases risk of CHB, HBV-HCC in males
MBL2	rs7096206	Influences the outcomes of HCC susceptibility, progressive tumor development, and clinical outcomes in HBV-HCC	Gu et al. (247)
	rs1800450	Modifies disease in patients after HBV infection, and affects the prognosis of patients with HBV-HCC
	rs11003123	Risk factor for HCC development in the Chinese population	Wang et al. (196)
MBL	rs7096206	Associated with polymorphisms in VDR/VEGF and IL-18 which collectively confer susceptibility to HCC in the Asian population	Quan et al. (246)
	Codon 52, Codon 54, Codon 57	Associated with disease prognosis in patients with HBV, severe hepatitis B (SHB) or LC. Not associated with HCC prognosis	Xu et al. (250)
	Codon 54	Associated with symptomatic hepatitis B cirrhosis and in patients with spontaneous bacterial peritonitis (SBP)	Yuen et al. (251)
MBL/MASP-2 complex	p.D371Y	Involved in C4 cleavage of MASP2 gene and susceptibility to HCV infection. High levels of plasma MASP-2 are found in Hep-C patients	Tulio et al. (265)
CD46	rs2796267	Associated with susceptibility and disease outcomes in HCC by modifying promoter activity. Also defines grave prognosis of resected patients with HCC	Liu et al. (148)