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. 2021 Feb 28;41:101921. doi: 10.1016/j.redox.2021.101921

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© 2021 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — Protective effect of taurine on the epithelial-mesenchymal transition processes in MELAS iPSC-derived RPE. (A–F) mRNA levels of the genes encoding epithelial-mesenchymal transition markers ZEB1 (A), SNAI1 (B), TWIST1 (C), ACTA (D), TGFB1 (E), and TGFB2 (F) in the control (454E2) and MELAS (A24#2) iPSC-derived RPE in the absence or presence of the treatment with taurine (n = 3). (G–J) Staining of the cells for ACTA (αSMA) (G, green; H), and NRF2 (I, green, counterstaining with DAPI in magenta; J) in MELAS (A24#2) iPSC-derived RPE in the absence or presence of the treatment with taurine (n = 6). *P < 0.05. Scale bar, 100 μm. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)