Table 1. Relationship between hsa_circ_0006220 expression and the clinicopathological features in patients with breast cancer.
| Characteristics | No. of cases [%] | hsa_circ_0006220 expression (mean ± SD) | P value |
|---|---|---|---|
| Age (year) | 0.9375 | ||
| ≥60 | 12 [24] | 0.408±1.002 | |
| <60 | 38 [76] | 0.399±1.152 | |
| Tumor size (cm) | 0.6018 | ||
| <2 | 5 [10] | 0.224±0.251 | |
| 2–5 | 38 [76] | 0.399±1.211 | |
| ≥5 | 7 [14] | 0.537±0.945 | |
| Lymphatic metastasis | 0.0341 | ||
| N0 | 30 [60] | 0.591±1.402 | |
| N1–3 | 20 [40] | 0.116±0.152 | |
| Pathological type | 0.0028 | ||
| Ductal carcinoma in situ | 6 [12] | 1.856±2.578 | |
| Invasive ductal carcinoma | 40 [80] | 0.211±0.564 | |
| Others | 4 [8] | 0.123±0.0782 | |
| Histological grade (invasive ductal carcinoma) (n=40) | 0.1041 | ||
| I | 3 [7.5] | 0.071±0.029 | |
| II | 33 [82.5] | 0.223±0.620 | |
| III | 4 [10] | 0.017±0.024 | |
| Estrogen receptor | 0.3695 | ||
| Absent | 9 [18] | 0.276±0.366 | |
| Present | 41 [82] | 0.428±1.213 | |
| Progesterone receptor | 0.9065 | ||
| Absent | 14 [28] | 0.199±0.308 | |
| Present | 36 [72] | 0.480±1.288 | |
| HER-2 | 0.1866 | ||
| Absent | 8 [16] | 0.594±1.207 | |
| 1+ | 17 [34] | 0.251±0.579 | |
| 2+ | 17 [34] | 0.609±1.626 | |
| 3+ | 8 [16] | 0.084±0.085 | |
| Ki-67 | 0.2331 | ||
| <14% | 6 [12] | 0.207±0.174 | |
| ≥14% | 44 [88] | 0.427±1.178 |
Italic P values indicate P<0.05. HER-2, human epidermal growth receptor 2.