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. 2021 Feb 24;12:625733. doi: 10.3389/fphar.2021.625733

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Copyright © 2021 Ma, Lin, Liu, Li, He, Fang and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Histopathological features of the flaps were assessed using hematoxylin and eosin (H&E) staining on day 7 after the operation; representative images acquired with a light microscope are shown (magnification,×100, ×200). Api reduced histopathological damage. (B) The microvascular density in zone 2 of the dorsal flap on day 7 after the operation. Api increased microvessel density. (C) Neutrophil density on day 7 after the operation. Api reduced neutrophil density.**p < 0.01 vs. control group. ^## p < 0.01 vs. Low-dose Api group.