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. 2021 Feb 24;12:625733. doi: 10.3389/fphar.2021.625733

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Copyright © 2021 Ma, Lin, Liu, Li, He, Fang and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative images after immunohistochemical staining for different pro-inflammatory cytokines 7 days after the operation (magnification, ×400). Expression levels of VEGF, TNF-α, IL-1β, and IL-6 in zone 2 of dorsal flaps. Api promoted the expression of VEGF and inhibited the expression of IL-1β, IL-6, and TNF-α. **p < 0.01 vs. control group. ^## p < 0.01 vs. Low-dose Api group.