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. 2021 Jan 21;11:588669. doi: 10.3389/fphar.2020.588669

FIGURE 7.

FIGURE 7

Cardiovascular responses to [Pyr1]apelin-13 at 50 nmol administered as a fourth dose following three successive doses of either saline pH9, CMF-019 or [Pyr1]apelin-13 in vivo. Graphs show changes in arterial pressure (A), contractility (dP/dtMAX) (B), left ventricular systolic pressure (LVSP; C), stroke volume (SV; D), cardiac output (CO; E), heart rate (HR; F) and relaxation (dP/dtMIN) (G) to 50 nmol [Pyr1]apelin-13 in anaesthetized male Sprague-Dawley rats previously administered with three doses of either saline (●, n = 4) or CMF-019 potassium salt (■, n = 8) or Pyr1]apelin-13 (▲, n = 5). The response to [Pyr1]apelin-13 after CMF-019 or [Pyr1]apelin-13 was compared by a Student’s t-test to that after saline control (***p < 0.001).