TABLE 1.
Major commercial companies researching and producing exosome products.
| Company | Product/Research |
|---|---|
| Aethlon medical | Development of exosomal-based candidate products for the diagnosis and management of neurological disorders and cancer |
| Anjarium biosciences | Focus on therapeutic RNA cargo, both long as well as short RNAs, including those that are chemically optimized for very high potency |
| Aruna biomedical | AB126, neuro exosomes used across the blood–brain barrier to treat stroke |
| Biocept | Focus on developing innovative diagnostic solutions all from a simple blood test, known as a liquid biopsy |
| Capricor therapeutics | CAP-2003, exosomes produced by cardiosphere-derived cells |
| Ciloa | Delivery of membrane proteins |
| Codiak biosciences | Exosomal targeted delivery of sting agonist or IL-12 |
| Creative medical technology holdings | Focused on regenerative medical solutions for unmet urological, neurological and orthopedic needs |
| ExananoRNA | Committed to promoting the transfer of biological nanotechnology, especially RNA nanotechnology, from laboratory research to clinical applications |
| ExoCoBio | A pharmaceutical R and D and cosmeceutical company. In the cosmeceutical business, ExoCoBio has launched its own exosome-based brands and products, such as EXOMAGETM, CelltweetTM, and ASCE + TM. |
| Exosome diagnostics | Develop novel and sensitive diagnostic methods based on exosomes, such as prostate, bladder, kidney, breast, glioblastoma, and other cancers |
| Exovita biosciences | Breast cancer treatment |
| Evox therapeutics | Development of exosomes for niemann-pick and duchenne muscular dystrophy |
| IBM | A new lab-on-a-chip technology separates smaller biological particles than before |
| MDimune | Drug delivery |
| Molecuvax | Cancer |
| Puretech | New milk exosome oral biologics for biological macromolecules (including antisense oligonucleotides) and complex small molecules |
| Regeneus | Donor adipose-derived MSCs secrete molecules (including cytokines, growth factors, and exosomes) to reduce pain and inflammation, and promote accelerated healing and repair |
| Reneuron | Large-scale production of exosomes from immortal stem cell lines |
| RoosterBio and exopharm | Advanced therapeutic extracellular vesicles/exosomes from adult stem cell sources for clinical practice |
| Stem cell medicine | MSC exosomes for autism treatment development |
| Tavec pharmaceuticals | miRNA delivery for cancer treatment |
| The cell factory | Candidate drug for EVs (CF-MEV-117) is being developed for the treatment of drug-resistant epilepsy in children |
| Theragnostex | Development of multiple analyses based on early cancer detection of exosomes to determine the best treatments specific to patients |
| VivaZome therapeutics | Development of advanced manufacturing processes |
| Ymir genomics | Two high-yield methods for separating EVs and extracellular nucleic acids from urine |
EVs, extracellular vesicles; IL-12, interleukin-12; R & D, research and development.