FIGURE 4.

Relative contribution of NO• and HNO to ACh-induced relaxation in rat carotid arteries. Cumulative concentration response curves to ACh in the presence of apamin + TRAM 34 plus either L-cysteine (n = 7–8) or HXC (n = 8). Carotid arteries isolated from (A) Sham (B) Diabetic rats. Indomethacin (10 µM) was always present in the Krebs’ buffer. Values are mean ± SEM, where n = number of animals. R_max vs control (#p < 0.05, ####p < 0.0001, one-way ANOVA, Dunnett’s post-hoc test). See Table 1 for pEC₅₀ and R_max values.