FIGURE 7.

Relative contribution of SNP-induced relaxation in rat carotid arteries. Cumulative concentration response curves to SNP in the absence (control) and presence of either apamin + TRAM 34 (n = 5–6), L-NAME + ODQ (n = 6–7) or apamin + TRAM 34 + L-NAME + ODQ (n = 5–6). Carotid arteries isolated from (A) Sham (B) Diabetic rats. Indomethacin (10 µM) was always present in the Krebs’ buffer. Values are mean ± SEM, where n = number of animals. R_max vs control (^# p < 0.05, one-way ANOVA, Dunnett’s post-hoc test). See Table 1 for pEC₅₀ and R_max values.