TABLE 5.
Alkaloids with angiogenic regulatory action.
| Source | Bioactive ingredient | Efficacy | Dose | Experimental model | Mechanism | Ref |
|---|---|---|---|---|---|---|
| Evodia rutaecarpa (Juss.) Benth. | Rutaecarpine | Antitumour | — | — | Inhibition of angiogenesis | Yin et al., 2016 |
| Evodiamine | Antitumour | — | — | Inhibition of angiogenesis | ||
| Goshuyuamide-Ⅰ | Antitumour | — | — | Inhibition of angiogenesis | ||
| N-formyldihydrorutaecarpine | Antitumour | — | — | Inhibition of angiogenesis | ||
| 1-Methyl-2-undecyl-4 (1H) -quinolone | Antitumour | — | — | Inhibition of angiogenesis | ||
| Dihydroevocarpine | Antitumour | — | — | Inhibition of angiogenesis | ||
| N-methylanthranylamide | Antitumour | — | — | Inhibition of angiogenesis | ||
| Limonoids calodendrolide | Antitumour | — | — | Inhibition of angiogenesis | ||
| Coptis chinensis Franch | Berberine | Antitumour | 5 μmol L−1 | Chick embryo chorioallantoic membrane model | Targeting binding and inhibiting VEGFR2 activity, blocking its mediated activation of AKt/mTOR/P70S6K signaling pathways, and then acting as an antiangiogenic agent | Li et al., 2019c; Wang et al., 2014 |
| Crataegus pinnatifida Bge | 5,2,4′-trihydroxy-6,7,5′-trimethoxyflavone (TTF1) | Antitumour | 5 μmol kg−1
10 μmol kg−1 20 μmol kg−1 |
Chick embryo chorioallantoic membrane model | Down regulation VEGF, KDR, bFGF, HIF-1α and COX-2 | Liu et al., 2011a |
| Capsicum annuum L | Capsaicin | Antitumour | — | — | Inhibition of angiogenesis | Liu et al., 2014 |
| Corydalis yanhusuo W. T. Wang | Alkaloids | Anti-angiogenesis | — | — | Targeted inhibition of vascular endothelial growth factor receptor signaling | Wan et al., 2020 |