Table 1. Univariate and multivariate Cox regression analysis in HCC.

Dataset	Variables	Univariate analysis			Multivariate analysis
		HR (95% CI)	P value		HR (95% CI)	P value
TCGA	Age (≥65/<65 years)	1.012 (0.618–1.657)	0.963		1.097 (0.650–1.851)	0.729
	Gender (male/female)	1.120 (0.666–1.881)	0.669		1.011 (0.577–1.771)	0.969
	TNM stage (I+II/III+IV)	2.750 (1.871–4.043)	<0.001		2.716 (1.288–5.727)	0.008
	Grade (G1+G2/G3+G4)	1.071 (0.731–1.567)	0.726		1.464 (0.759–2.824)	0.254
	Ishak Score (0-4/5-6)	0.841 (0.473–1.495)	0.555		1.700 (0.809–3.570)	0.161
	Child Pugh Grade (A/B-C)	2.185 (1.070–4.462)	0.032		2.267 (0.941–5.459)	0.068
	Vascular invasion (yes/no)	1.461 (0.943–2.262)	0.089		2.013 (1.023–3.963)	0.043
	P53 (mutation/wild)	1.579 (1.061–2.353)	0.024		0.728 (0.312–1.699)	0.462
	Residual tumor (R0/R1-R2)	1.805 (0.911–3.577)	0.090		1.745 (0.356–8.570)	0.492
	ALDOA (high/low)	2.744 (1.658–4.541)	<0.001		4.847 (1.779–13.204)	0.002
GSE14520	Age (≥60/<60 years)	0.855 (0.489–1.494)	0.583		1.054 (0.569–1.951)	0.868
	Gender (male/female)	1.700 (0.821–3.522)	0.153		1.223 (0.579–2.604)	0.592
	ALT (>50/≤50 U/L)	1.079 (0.703–1.658)	0.727		0.848 (0.538–1.338)	0.479
	Tumor Size (>5/≤5 cm)	1.925 (1.253–2.958)	0.003		0.882 (0.487–1.598)	0.678
	Multinodular (yes/no)	1.592 (0.986–2.571)	0.057		0.404 (0.204–0.798)	0.009
	Cirrhosis (yes/no)	4.624 (1.137–18.802)	0.032		4.209 (1.021–17.349)	0.046
	AFP (>300/≤300 ng/mL)	1.629 (1.063–2.497)	0.025		1.272 (0.806–2.008)	0.300
	TNM stage (III+IV/I+II)	3.5163 (2.241–5.514)	<0.001		1.646 (0.781–3.469)	0.191
	ALDOA (high/low)	2.029 (1.318–3.125)	0.001		1.674 (1.047–2.675)	0.031

HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; TCGA, The Cancer Genomic Atlas; TNM, tumor, node, metastasis; ALDOA, aldolase A; AFP, alfa-fetoprotein