Table 2. Baseline characteristics of patients with vs. without biliary atresia in the derivation cohort (N=227).
| Parameters | BA (n=82) | Non-BA (n=145) | P |
|---|---|---|---|
| Birth weight (g) | 3,252.0±460.7 | 3,090.0±485.1 | 0.015 |
| Age at admission (day) | 46.0±15.6 | 44.7±19.9 | 0.586 |
| Weight at admission (g) | 4,508.8±900.1 | 4,092.6±1,022.0 | 0.002 |
| Preterm | 5 (6.1) | 16 (11.0) | 0.218 |
| Male | 51 (62.2) | 86 (59.3) | 0.67 |
| Clinical measures | |||
| Recurrent jaundice | 20 (24.4) | 36 (24.8) | 0.941 |
| clay-colored stools | 42 (51.2) | 29 (20.0) | <0.001 |
| Hepatomegaly | 38 (46.3) | 59 (40.7) | 0.408 |
| Splenomegaly | 10 (12.2) | 21 (14.5) | 0.630 |
| Liver function test | |||
| TBA at admission (μmol/L) | 103.1 (76.2, 127.9) | 91.0 (64.8, 132.5) | 0.091 |
| ΔTBA | −0.9 (−19.9, 13.0) | −10.9 (−46.6, 11.0) | 0.013 |
| ALT at admission (U/L) | 124.0 (73.3, 213.5) | 115.5 (61.8, 184.5) | 0.446 |
| ΔALT (U/L) | 14.5 (−21.0, 48.3) | 6.0 (−28.3, 81.3) | 0.744 |
| AST at admission (U/L) | 193.0 (129.3, 308.5) | 168.0 (98.0, 290.3) | 0.109 |
| ΔAST (U/L) | 0.1 (−46.3, 50.3) | −12.5 (−82.5, 53.8) | 0.252 |
| AKP at admission (U/L) | 461.0 (358.0, 624.5) | 488.5 (349.0, 619.3) | 0.656 |
| ΔAKP (U/L) | −32.5 (−100.5, 45.5) | −57.5 (−146.0, 26.3) | 0.080 |
| TBIL at admission (μmol/L) | 159.7 (138.6, 187.5) | 149.7 (103.0, 211.1) | 0.185 |
| ΔTBIL (μmol/L) | −5.3 (−26.9, 16.6) | −47.6 (−83.6, −14.4) | <0.001 |
| DBIL at admission (μmol/L) | 96.3 (72.7, 126.5) | 82.0 (50.2, 116.8) | 0.004 |
| ΔDBIL (μmol/L) | 7.4 (−8.4, 28.4) | −15.8 (−40.8, 6.7) | <0.001 |
| GGT at admission (U/L) | 427.0 (221.3, 731.5) | 133.0 (81.8, 218.5) | <0.001 |
| ΔGGT(U/L) | 10.5 (−37.5, 83.3) | −10.5 (−42.0, 36.5) | 0.06 |
| ALB at admission (g/L) | 37.4 (34.7, 41.0) | 37.5 (34.4, 39.9) | 0.780 |
| ΔALB (g/L) | −0.8 (−4.2, 2.1) | −1.0 (−3.3, 1.6) | 0.822 |
| Ultrasonography findings | |||
| Abnormal gallbladder (N, %) | 47 (57.3) | 24 (16.6) | <0.001 |
| Triangular cord sign | 32 (39.0) | 5 (3.4) | <0.001 |
BA, biliary atresia; TBA, total bile acid; ALT, alanine transaminase; AST, aspartate transaminase; AKP, alkaline phosphatase; TBIL, total bilirubin; DBIL, direct bilirubin; GGT, γ-glutamyl transferase; ALB, albumin. Data are presented as mean ± standard deviation, N (%), or median (IQR, inter quartile range).