Table 4. Effectiveness of risk stratification based on the screen model and clay stool of biliary atresia in derivation and validation cohort.
Biliary atresia screen method | Cutoffs | Derivation cohort (n=227) | Validation cohort (n=234) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
No. of cholestatic infants classified into each risk group, N (%) | No. of biliary atresia classified into each risk group, N (%) | Detection rate of biliary atresia in each risk group (%) | Detection rate of biliary atresia in the total population (%) | No. of cholestatic infants classified into each risk group, N (%) | No. of cases classified into each risk group, N (%) | Detection rate of esophageal high-grade lesions in each risk group (%) | Detection rate of biliary atresia in the total population (%) | |||
High risk group in the screen model | ≥0.49998 | 77 (33.9) | 66 (80.5) | 85.7 | 82/227 (36.1) | 85 (36.3) | 72 (80.0) | 84.7 | 90/234 (38.5) | |
Intermediate risk group in the screen model | <0.49998, >0.05317 | 83 (36.6) | 16 (19.5) | 19.3 | 85 (36.3) | 18 (20.0) | 21.2 | |||
Low risk group in the screen model | ≤0.05317 | 67 (29.5) | 0 | 0 | 64 (27.3) | 0 | 0 | |||
Clay-colored stools in the total population | Presence | 71 (31.3) | 42 (51.2) | 59.2 | 62 (26.5) | 35 (38.9) | 56.5 |