Figure 2.

ApoE^−/− mouse AS plaque in aortic arch and thoracic aorta (miR-155 mimic vs. inhibitor). Macroscopic images showed the successful establishment of atherosclerotic model of ApoE^−/− mice after 12-week high-fat diet feeding. Representative macro specimen demonstrated aortic arch and thoracic aortas stained with Oil Red O (ORO). The graph shows quantification of atherosclerosis burden and miR-155 mimic group expressed significant anti-atherosclerotic effect on AS progression than that of miR-155 inhibitor group. *, miR-155 vs. 155 inhibitor group, P<0.05.